akụkọ

Hydroxypropyl beta-cyclodextrin, nke a makwaara dịka (2-hydroxypropyl) -β-cyclodextrin, bụ atọm hydrogen dị na otu 2-, 3-, na 6-hydroxyl nke ihe fọdụrụ na glucose dị na β-cyclodextrin (β-CD) nke hydroxypropyl dochie ka ọ bụrụ hydroxypropoxy. HP-β-CD abụghị naanị na ọ nwere mmetụta envelopu dị mma na ọtụtụ ihe dị iche iche dịka β-CD, kamakwa ọ nwere uru nke mmiri dị elu na-agbaze ma na-eme ka ọnụego ntọhapụ na bioavailability nke ọgwụ ndị e tinyere na vivo dịkwuo mma. Na mgbakwunye, HP-β-CD bụ ihe na-enye ọgwụ nwere data nchekwa kachasị ukwuu anakọtara na enweghị mmetụta ọjọọ. Enwere ike iji HP-β-CD dị ka ihe nchebe protein na ihe na-eme ka ọ kwụsie ike.

Hydroxypropyl beta-cyclodextrin bụ ntụ ọcha ma ọ bụ ọcha amorphous ma ọ bụ kristal; Enweghị isi, ọ dị ntakịrị ụtọ; Mmiri siri ike na-akpali. Ngwaahịa a na-agbaze ngwa ngwa na mmiri, ọ na-agbaze ngwa ngwa na methanol, ethanol, ọ fọrọ nke nta ka ọ ghara ịgbaze na acetone, trichloromethane.

Mgbaze nkehydroxypropyl-B-cyclodextrinN'ime mmiri dị mma nke ukwuu, a pụkwara iji mmiri gwakọta ọkwa nnọchi nke 4 na karịa n'ogo ọ bụla, a pụkwara ịgbazekwa ya na ethanol na methanol 50%. O nwere ụfọdụ hygroscopicity. Mana ọrụ elu na ọrụ hemolytic dị obere. Ọ naghị akpasu akwara iwe ma ọ bụ ihe na-eme ka ihe mgbaze na ọgwụ dịkwuo mma maka ịgba ọgwụ.

Gịnị ka a na-eji Hydroxypropyl beta-cyclodextrin eme?

N'ihe gbasara nri na ihe na-esi ísì ụtọ

Hydroxypropyl beta-cyclodextrin nwere ike ime ka nkwụsi ike na arụmọrụ ogologo oge nke molekul nri ka mma, kpuchie ma ọ bụ dozie isi ọjọọ na uto nke molekul nri nri, ma melite usoro mmepụta na ịdị mma nke ngwaahịa.

Na ihe ịchọ mma

Enwere ike iji ihe ndị e ji achọ mma mee ihe dị ka ihe na-eme ka ihe sie ike, ihe na-eme ka ihe na-esi ísì ụtọ pụta ìhè, ihe na-eme ka ihe na-esi ísì ụtọ ghara ịdị nkọ, wdg., nke nwere ike ibelata mkpali nke ihe ndị dị ndụ na ihe ịchọ mma na akpụkpọ ahụ na akpụkpọ ahụ, mee ka ihe ndị na-arụ ọrụ dịkwuo mma, ma gbochie mgbanwe na oxidation nke ihe oriri. O nwere ụfọdụ hygroscopicity.

N'ihe gbasara ọgwụ

Hydroxypropyl beta-cyclodextrinnwere ike ime ka ọgwụ ndị a na-anaghị agbaze n'ime mmiri ka mma, mee ka ọgwụ kwụsie ike, melite ịdị irè nke ọgwụ, mee ka nkwadebe ọgwụ dịkwuo mma ma ọ bụ belata dose, gbanwee ma ọ bụ chịkwaa ọsọ mwepụta ọgwụ, ma belata nsí ọgwụ. Enwere ike iji ya dị ka ihe na-ebu ọgwụ ọnụ, ịgba ọgwụ, usoro nnyefe ọgwụ mucosal (gụnyere mucosa imi, rectum, cornea, wdg), sistemụ nnyefe ọgwụ transdermal absorption, ọgwụ lipophilic ezubere iche, enwere ike iji ya dị ka ihe nchebe protein na ihe na-eme ka ọ kwụsie ike.