ozi

Hydroxypropyl beta-cyclodextrin, nke a makwaara dị ka (2-hydroxypropyl) -β-cyclodextrin, bụ hydrogen atom na 2-, 3-, na 6-hydroxyl otu nke glucose residues na β-cyclodextrin (β-CD) nke hydroxypropyl dochie anya. hydroxypropoxy. HP-β-CD abụghị naanị nwere mmetụta dị mma envelopu n'ọtụtụ ogige dị ka β-CD, kamakwa ọ nwere uru dị na oke mmiri solubility na ịkwalite ọnụego ntọhapụ na bioavailability nke ọgwụ encapsulated na vivo. Na mgbakwunye, HP-β-CD bụ ihe mgbakwunye ọgwụ nwere data nchekwa kachasị anakọtara yana enweghị mmetụta ọjọọ. HP-β-CD nwekwara ike iji dị ka ihe nchekwa protein na stabilizer.

Hydroxypropyl beta-cyclodextrin bụ ọcha ma ọ bụ ọcha amorphous ma ọ bụ crystalline ntụ ntụ; Enweghị isi, dịtụ ụtọ; Ntinye mmiri siri ike. Ngwaahịa a na-adị mfe mgbaze na mmiri, na-adị mfe soluble na methanol, ethanol, ọ fọrọ nke nta ka ọ ghara ịsacha na acetone, trichloromethane.

The solubility nkehydroxypropyl-B-cyclodextrinna mmiri dị ezigbo mma, na ngbanwe ogo nke 4 na n'elu nwere ike miscible na mmiri n'ụzọ ọ bụla, na nwekwara ike agbaze na 50% ethanol na methanol. Ọ nwere ụfọdụ ikwu hygroscopicity. Ma ọrụ elu dị n'elu na ọrụ hemolytic dị ntakịrị. Ọ nweghị ihe mgbakasị ahụ n'ahụ ahụ ma bụrụ ezigbo ihe nkwalite ihe mgbaze yana ihe mgbakwunye ọgwụ maka ịgba ọgwụ.

Kedu ihe a na-eji Hydroxypropyl beta-cyclodextrin maka?

N'ubi nri na ngwa nri

Hydroxypropyl beta-cyclodextrin nwere ike imeziwanye nkwụsi ike na arụmọrụ ogologo oge nke ụmụ irighiri ihe oriri, kpuchie ma ọ bụ dozie isi ísì ọjọọ na uto nke mkpụrụ ndụ ihe oriri na-edozi ahụ, ma melite usoro mmepụta na àgwà ngwaahịa.

N'ihe ịchọ mma

Enwere ike iji akụrụngwa nke ịchọ mma dị ka stabilizers, emulsifiers, deodorizers, wdg, nke nwere ike belata mkpali nke mkpụrụ ndụ ihe nketa na ihe ịchọ mma na akpụkpọ anụ na akpụkpọ anụ mucous, na-eme ka nkwụsi ike nke ihe ndị na-arụ ọrụ na-arụ ọrụ, na-egbochi mgbanwe na oxidation nke nri. . Ọ nwere ụfọdụ ikwu hygroscopicity.

Na ngalaba ọgwụ

Hydroxypropyl beta-cyclodextrinnwere ike melite solubility mmiri nke ọgwụ ndị a na-apụghị imeri emeri, mụbaa nkwụsi ike ọgwụ, melite bioavailability ọgwụ, mee ka nrụpụta ọgwụ dị irè ma ọ bụ belata usoro onunu ogwu, gbanwee ma ọ bụ chịkwaa ngwa ngwa ntọhapụ nke ọgwụ, ma belata nsị ọgwụ. Enwere ike iji ya dị ka onye na-ebu ọgwụ ọnụ, injections, usoro nnyefe ọgwụ mucosal (gụnyere mucosa imi, rectum, cornea, wdg), usoro nnyefe ọgwụ transdermal, ọgwụ lipophilic ezubere iche, ma nwekwara ike iji ya dị ka ihe nchebe protein na stabilizer.