ozi

Maka nlekọta anụ ahụ dị irè, n'ezie, ọ bụ ihe a na-apụghị izere ezere inwe echiche ụfọdụ nke ihe ndị na-emepụta ihe, ọ bụghị nanị ịkwalite ngwaahịa ahụ, kamakwa ihe ndị dị na ngwaahịa ahụ. Taa, ka anyị kwuo maka "carnosine" nke ihe eji elekọta anụ ahụ.

Gịnị bụ 'Carnosine'
Carnosine bụ dipeptide mejupụtara beta-alanine na L-histidine, nke nwere ọdịnaya dị elu na mọzụlụ na mgbochi ụbụrụ. Carnosine nwere ihe antioxidant dị elu ma nwee ike ịbọ ọbọ n'efu na ahụ.

Kedu ka 'carnosine' si arụ ọrụ
Carnosine nwere ike ịbawanye nguzogide akpụkpọ ahụ, nọgide na-eto eto nke mkpụrụ ndụ site n'ịnọgide na-arụ ọrụ nke mkpụrụ ndụ n'ụdị dị iche iche na ọnọdụ radical free, na-akwalite mmepụta nke collagen, na-eme ka akpụkpọ ahụ dịkwuo mma.

Ọrụ nke 'carnosine'
Carnosine nwere ike ịbawanye nguzogide akpụkpọ ahụ, nọgide na-eto eto nke mkpụrụ ndụ site n'ịnọgide na-arụ ọrụ nke mkpụrụ ndụ n'ụdị dị iche iche na ọnọdụ radical free, na-akwalite mmepụta nke collagen, na-eme ka akpụkpọ ahụ dịkwuo mma. The chemical ọdịdị nkeL-carnosinebụ nhazi nke beta-alanine na L-histidine site n'omume nke carnosine synthase. Carnosine nwere atụmanya ngwa sara mbara na ngalaba ọgwụ, nlekọta ahụike, na ịdị ọcha n'ihi akụrụngwa antioxidant ya, nsonaazụ radical free, chelation na ọla mgbanwe, neuroprotection, nkwalite ọgwụgwọ ọnya na mgbochi ịka nká.

1. Ngwa nke carnosine na ụlọ ọrụ nri
Isi ihe dị na mmanụ na nri bụ ngwakọta nke glycerides fatty acid dị iche iche. N'ihi mmeghachi omume radical free nke unsaturated fatty acid glycerides n'oge nchekwa, a na-emepụta peroxides na aldehydes na-esi ísì ụtọ ma ọ bụ acid carboxylic nwere obere eriri carbon. Ya mere, iri nri nwere abụba peroxides ga-akwalite n'ihu lipid peroxidation n'ime ahụ mmadụ ma bute ọrịa dị iche iche. Ya mere, a na-ejikarị butylated hydroxyanisole, dibutylated hydroxytoluene, propyl gallate, wdg na nhazi nri na nchekwa iji gbochie peroxidation abụba, mana arụmọrụ ha ga-ebelata na usoro ikpo ọkụ nke nhazi nri, ọ nwekwara ụfọdụ nsị. L-carnosine nwere ike ọ bụghị nanị na-egbochi abụba oxidation nke ọma, kamakwa ọ nwere nnukwu nchekwa na ọrụ nlekọta ahụike. Ya mere, L-carnosine bụ ihe bara uru na ezigbo antioxidant nri.
2. Ngwa nke carnosine na ọgwụ na nlekọta ahụike
(1) Carnosine na Antioxidant

Carnosine nwere ike ọ bụghị naanị iji imidazole mgbanaka N atom na peptide bond N atom na histidine residues iji chelate metal ion na igbochi abụba oxidation nke metal ion kpatara, kamakwa histidine n'akụkụ yinye nke carnosine nwere ikike ijide hydroxyl radicals. Ọ nwere ike igbochi oxidation nke abụba sitere na ion na-abụghị metal. Ya mere, dị ka ihe na-arụ ọrụ antioxidant multifunctional, carnosine nwere ike chebe akpụkpọ ahụ cell ma bụrụ onye na-ekpochapụ radical na-enweghị mmiri. , nwere ike igbochi peroxidation nke akpụkpọ ahụ cell. E jiri ya tụnyere ihe ndị ọzọ na-eme ihe na-eme ihe ndị dị ndụ dị ka VC, carnosine nwere ikike antioxidant siri ike. Na mgbakwunye na igbochi usoro peroxidation nke akpụkpọ ahụ cell, carnosine nwekwara ike igbochi usoro nke mmeghachi omume peroxidation intracellular ndị ọzọ, ya bụ, carnosine nwere ike igbochi usoro ọ bụla nke mmeghachi omume oxidation na dum peroxidation chain na organism. Ọrụ nke antioxidants dị ka VC bụ igbochi free radicals ịbanye n'ime anụ ahụ, ya bụ, ha nwere ike igbochi naanị usoro peroxidation mmiri nke akpụkpọ ahụ cell, na enweghị ike ime ihe ọ bụla maka radicals free nke batara na cell.
(2) Carnosine na ọnya afọ

Ọrịa ọnya peptic bụ ọrịa sistemu mgbari nri na-adịghị ala ala zuru ụwa ọnụ, ihe ndị akọwapụtara nke na-akpata ọnya amabeghị nke ọma ugbu a, mana pathology kwenyere na ihe ike ike (dịka gastric acid, pepsin secretion, ọrịa Helicobacter pylori) na mgbochi ma ọ bụ cellular kpatara ya. ahaghị nhata nke ihe nchebe (mmiri imi, ihe nzuzo bicarbonate, mmepụta prostaglandin). Usoro nchebe eke nke afọ bụ: ọ na-etolite akwa oyi akwa nke mucosa gastric nke na-arụ ọrụ dị ka ihe mgbochi nchebe iji chebe mkpụrụ ndụ ndị dị na mkpuchi. Ihe nzuzo na-aga n'ihu nke akpụkpọ ahụ mucous na-echebe afọ, mana oke nzuzo nwere ike ịkpata ọnya afọ. Nnyocha achọpụtala na zinc-carnosine nke a na-ewere na nri nwere ike igbochi ọnya ọnya nke ọma, ọ nwere ike idobe iguzosi ike n'ezi ihe nke afọ na usoro nchebe okike ya nke ọma, nke a bụ n'ihi ihe ndị na-eme ka carnosine na-ahụ maka antioxidant, nkwụsi ike akpụkpọ ahụ, njikwa ọgwụ ọgwụ nke mgbochi na nrụzi anụ ahụ. Dị ka ule ụlọ ọgwụ si kwuo, mgbe ha nwụsịrị zinc-carnosine ruo izu asatọ, 70% nke ndị ọrịa na-aṅụ ọgwụ ahụ gosipụtara ọganihu dị ukwuu, na 65% nke ọnya afọ na-emeziwanye site na gastroscopy.
(3) Carnosine na nchịkwa mgbochi

Nzaghachi nke mgbochi bụ ọrụ physiological nke na-ejigide homeostasis ma na-achịkwa ya site na ihe ndị na-arụ ọrụ physiologically na ihe ndị dị ndụ. Immunomodulators na-ezo aka na ọgwụgwọ nke otu klas nke ọrịa na-akpata site na nkwụsị nke usoro ahụ ji alụso ọrịa ọgụ, a na-ejikwa ya weghachi nzaghachi mgbochi ahụ, na-egbochi ọdịda ya na-adịghị mma ma ọ bụ gbochie nzaghachi ngwa ngwa. Ọtụtụ n'ime immunomodulators dị ugbu a na-emepụta site na usoro njikọ kemịkal, nke nwere ụfọdụ nsí na mmetụta. Nnyocha egosiwo na carnosine nwere ọrụ immunomodulatory, na ọ bụ naanị ihe na-arụ ọrụ physiologically a chọtara ugbu a maka immunomodulation, ma ejiri ya mee ihe n'ọtụtụ ebe n'ịgwọ ọrịa dị iche iche nke na-alụso ọrịa ọgụ na ọrịa ndị na-akpata ọrịa na-adịghị mma.