akụkọ

Maka nlekọta akpụkpọ ahụ dị irè, n'ezie, ọ dịghị mkpa inwe echiche ụfọdụ gbasara ihe ndị e ji mee ya, ọ bụghị naanị nkwalite ngwaahịa ahụ, kamakwa ihe ndị e ji mee ya. Taa, ka anyị kwuo maka "carnosine" nke ihe ndị e ji eme ihe na ngwaahịa nlekọta akpụkpọ ahụ.

Gịnị bụ 'Carnosine'
Carnosine bụ dipeptide nke mejupụtara beta-alanine na L-histidine, nke nwere nnukwu ọdịnaya n'ime akwara na ngọngọ ụbụrụ. Carnosine nwere nnukwu ihe antioxidant ma nwee ike iwepụ ihe ndị na-emebi emebi n'ahụ.

Otu 'carnosine' si arụ ọrụ
Carnosine nwere ike ime ka akpụkpọ ahụ ghara iguzogide ọrịa, mee ka mkpụrụ ndụ dị n'oge ntorobịa ha na-arụ ọrụ site n'ịnọgide na-arụ ọrụ nke mkpụrụ ndụ n'ime eriri zuru oke na ọnọdụ free radicals, kwalite mmepụta nke collagen, ma mee ka akpụkpọ ahụ na-agbanwe agbanwe.

Ọrụ nke 'carnosine'
Carnosine nwere ike ime ka akpụkpọ ahụ ghara iguzogide ọrịa, mee ka mkpụrụ ndụ dị obere na-arụ ọrụ site n'ịnọgide na-enwe ọrụ nke mkpụrụ ndụ n'ime eriri zuru oke na ọnọdụ free radicals, kwalite mmepụta nke collagen, ma mee ka akpụkpọ ahụ na-agbanwe agbanwe.L-carnosinebụ mmepụta nke beta-alanine na L-histidine site na ọrụ nke carnosine synthase. Carnosine nwere ohere sara mbara maka ojiji n'ọhịa nke ọgwụ, nlekọta ahụike, na ịdị ọcha n'ihi ihe ndị na-egbochi antioxidant ya, mmetụta ya na-ewepụ ihe ndị na-egbu egbu n'efu, chelation na ígwè mgbanwe, nchebe neuro, nkwalite ọgwụgwọ ọnya, na mgbochi ịka nká.

1. Itinye carnosine n'ọrụ n'ụlọ ọrụ nri
Isi ihe dị na mmanụ dị n'ime nri bụ ngwakọta nke ọtụtụ fatty acid glycerides. N'ihi mmeghachi omume free radical nke unsaturated fatty acid glycerides n'oge nchekwa, a na-emepụta peroxides na-esi ísì ọjọọ ma ọ bụ carboxylic acid nwere obere carbon agbụ. Ya mere, iri nri nwere abụba peroxides ga-akwalite lipid peroxidation n'ahụ mmadụ ma na-ebute ọrịa dị iche iche. Ya mere, a na-ejikarị butylated hydroxyanisole, dibutylated hydroxytoluene, propyl gallate, wdg eme ihe na nhazi nri na nchekwa iji gbochie abụba peroxidation, mana arụmọrụ ha ga-ebelata na usoro kpo oku nke nhazi nri, ọ nwekwara ụfọdụ nsí. L-carnosine enweghị ike igbochi abụba oxidation nke ọma, kamakwa ọ nwere ọrụ nchekwa na nlekọta ahụike dị elu. Ya mere, L-carnosine bụ antioxidant nri bara uru ma dị mma.
2. Itinye carnosine n'ọrụ n'ọgwụ na nlekọta ahụike
(1) Carnosine na Antioxidant

Carnosine enweghị ike iji mgbanaka imidazole N atom na njikọ peptide N atom na ihe fọdụrụ histidine iji chelate ion metal ma gbochie oxidation abụba nke ion metal kpatara, kamakwa histidine dị n'akụkụ nke carnosine nwere ike ijide radicals hydroxyl. Ọ nwere ike igbochi oxidation nke abụba nke ion ndị na-abụghị metal kpatara. Ya mere, dị ka ihe na-arụ ọrụ antioxidant dị iche iche, carnosine nwere ike ichebe akpụkpọ ahụ sel nke ọma ma bụrụ ihe na-agbaze mmiri na-enweghị radical. , nwere ike igbochi peroxidation nke akpụkpọ ahụ sel. Ma e jiri ya tụnyere antioxidants ndị ọzọ dị ndụ dị ka VC, carnosine nwere ikike antioxidant siri ike. Na mgbakwunye na igbochi usoro peroxidation nke akpụkpọ ahụ sel, carnosine nwekwara ike igbochi usoro mmeghachi omume peroxidation intracellular ndị ọzọ, ya bụ, carnosine nwere ike igbochi usoro ọ bụla nke mmeghachi omume oxidation na yinye peroxidation niile na ahụ. Ọrụ nke antioxidants dịka VC bụ igbochi radicals efu ịbanye n'ime anụ ahụ, ya bụ, ha nwere ike igbochi usoro peroxidation mmiri mmiri nke akpụkpọ ahụ sel, ha enweghịkwa ike ime ihe ọ bụla maka radicals efu ndị batara na sel ahụ.
(2) Carnosine na ọnya afọ

Ọrịa ọnya afọ bụ ọrịa zuru ụwa ọnụ nke na-adịghị ala ala, ihe ndị na-akpata ọnya afọ adịghịkwa apụta ìhè ugbu a, mana ọrịa ahụ kwenyere na ihe ndị na-eme ihe ike (dịka acid gastric, secretion pepsin, Helicobacter pylori infection) na mgbochi ma ọ bụ cell. Ihe kpatara ya bụ enweghị nguzozi nke ihe nchebe (nsị imi, secretion bicarbonate, mmepụta prostaglandin). Usoro nchekwa eke nke afọ bụ: ọ na-emepụta akwa dị arọ nke mucosa afọ nke na-arụ ọrụ dị ka ihe mgbochi nchebe iji chebe mkpụrụ ndụ dị n'ime mkpuchi ahụ. Ịmịpụta na-aga n'ihu nke akpụkpọ ahụ mucous na-echebe afọ, mana oke mmiri nwere ike ibute ọnya afọ. Ọmụmụ ihe achọpụtala na zinc-carnosine a na-aṅụ na nri nwere ike igbochi ọnya afọ nke ọma, ọ nwere ike ịnọgide na-eguzosi ike n'ezi ihe nke afọ na usoro nchebe ya eke, nke a bụ n'ihi ihe ndị na-egbochi ọrịa carnosine, nkwụsi ike na akpụkpọ ahụ, nhazi Njirimara ọgwụ nke anụ ahụ ji alụso ọrịa ọgụ na ndozi. Dịka nnwale ahụike si kwuo, mgbe ha ṅụsịrị zinc-carnosine ruo izu asatọ, 70% nke ndị ọrịa were ọgwụ ahụ gosipụtara mmụba dị ukwuu, 65% nke ọnya afọ ka emechara site na gastroscopy.
(3) Carnosine na njikwa ahụ ji alụso ọrịa ọgụ

Mmeghachi omume mgbochi ọrịa bụ ọrụ nke ahụ nke na-eme ka homeostasis dịgide ma na-achịkwa ya site na ihe ndị na-arụ ọrụ n'ahụ mmadụ n'ime ihe ndị dị ndụ. Ọgwụ mgbochi ọrịa na-ezo aka na ọgwụgwọ nke otu ụdị ọrịa ndị ọrịa na-akpata site na nkwarụ ahụ ji alụso ọrịa ọgụ, a na-ejikwa ha eme ihe iji weghachi nzaghachi ahụ ji alụso ọrịa ọgụ, gbochie mbelata ya na-adịghị mma ma ọ bụ gbochie nzaghachi ngwa ngwa ya. Ọtụtụ n'ime ọgwụ mgbochi ọrịa ndị dị ugbu a na-emepụta site na usoro mmepụta kemịkalụ, nke nwere ụfọdụ ihe na-egbu egbu na mmetụta ọjọọ. Ọmụmụ ihe egosila na carnosine nwere ọrụ immunomodulatory, ọ bụkwa naanị ihe na-arụ ọrụ n'ahụ mmadụ nke a hụrụ ruo ugbu a maka immunomodulation, a na-ejikwa ya eme ihe nke ukwuu n'ịgwọ ọrịa dị iche iche na ọrịa ndị ọrịa na-adịghị mma na-akpata.